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21c Museum Hotels

What can you expect to see when you visit a 21c Museum Hotel? Nothing expected, that’s for sure.

21c Museum Hotels is an example of how to successfully bridge the worlds of art and hospitality. These stays have been detailed as “a hometown hero with a boutique sensibility and a fabulous private art collection” by Condé Nast, and “one of the pioneering examples of bridging the worlds of art and hospitality” by the New York Times. Founded by Laura Lee Brown and Steve Wilson – two contemporary art collectors and preservationists who believe in the power of contemporary art – each property is crafted as a location where guests can consume global culture and connect with local communities within a multi-venue contemporary art museum, boutique hotel, and chef-driven restaurant.

Experience their curated rotating exhibitions, commissioned site-specific installations, and regular cultural programming at each location while just an elevator ride away from your plush hotel room retrofitted into modern-yet-historical living spaces. Each restaurant in this family of hotels is led by a dedicated chef that designs dishes that are committed to quality, support regional farmers and producers, and provide a unique look into a region’s local cuisine. This collection of unique stays not only boasts cutting-edge modernity but is also set in ideal locations to experience your destination of choice. Whether you’re stepping out to experience the buzzing energy of the city or a woodland hike, these hotels provide guests of all kinds with a home base that is both invigorating and soothing.

At 21c Museum Hotels, get ready to experience it all.


21c Museum Hotels has been selected to bring the award-winning boutique hotel and contemporary art museum to downtown St. Louis, restoring the YMCA building located at 1528 Locust Street and bringing a new kind of cultural and travel experience to the city with exhibitions, meeting and event spaces showcasing rotating curated exhibitions, interactive site-specific art installations, and a roster of cultural programming based on collaborations with local and national arts organizations. Mandelbaum Properties and 21c Museum Hotels have announced a partnership to bring the award-winning boutique hotel and contemporary art museum to downtown Des Moines – a focal point for their mixed-use project, The Fifth, slated for completion in 2022.  In addition to 21c, the mixed use project will offer 209 luxury apartments, a dine-in movie theater, curated retail space, and a public parking garage.
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